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[169] [170] According to a Cochrane review on withdrawal in individuals who compulsively use amphetamine and methamphetamine, "when chronic heavy users abruptly discontinue amphetamine use, many report a time-limited withdrawal syndrome that occurs within 24 hours of their last dose." [171] This review noted that withdrawal symptoms in chronic, high-dose users are frequent, occurring in roughly 88% of cases, and persist for 34 weeks with a marked "crash" phase occurring during the first week

FXS, Rett syndrome, and Dup15q patients exhibit epilepsy at rates as high as 80% (139)

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