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Synovial cells cotransfected with miRNA-125 mimics, and PARP2-siRNA had significantly lower expression of pro-inflammatory cytokines, MMP-1, p-PI3K, p-Akt, and p-mTOR in comparison with the negative groups

Phase 2 dose-finding trial Published in The Lancet in 2021, this multicenter, randomized, double-blind trial tested cagrilintide doses ranging from 0.3 mg to 4.5 mg weekly in people with overweight or obesity