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Spironolactone is mild diuretic but also has other attributes which in some cases makes it a useful supplemental drug to cavaliers in CHF, when combined with the others -- pimobendan, ACE-inhibitor, and diuretic -- to delay the dog's death

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For patients who experience severe "histamine dumps" at night, which can cause insomnia, sudden tachycardia, or night sweats, taking the dose in the late afternoon or early evening may provide targeted mast cell stabilization during the most vulnerable hours

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