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10.1038/s41467-018-05944-5 232 RossnerP.OrhanH.KoppenG.SakaiK.SantellaR

The answer is in the long-range interactions indicated by the red arrows in Figure 1

Recent studies have highlighted the role of mitochondrial impairment and altered energy metabolism as key contributors to the pathophysiology of GWS, with their severity correlating to disease progression in 19 veterans suffering from GWS and 17 healthy controls, comparing these factors to markers of peripheral inflammation (Golomb et al., 2023)

We believe its the single most critical factor