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Preclinical research in animal models has identified GLP-1 receptors in synovial tissue, cartilage, and bone, suggesting potential for direct effects on joint structures

In addition to SGLT2 inhibitors and GLP-1 receptor agonists, finerenone, a nonsteroidal mineralocorticoid receptor antagonist, has demonstrated significant cardiovascular and kidney-protective effects in people with type 2 diabetes mellitus and CKD or HF [129-132]