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The binding site in S for COPI is sub-optimal The COPI binding region comprises KLHYT which differs somewhat from the canonical KXKXX or KKXX C-terminal COPI binding motif 35,39 , and it has been speculated for SARS-CoV that this non-canonical motif might allow more S to reach the surface, although this was not tested experimentally 20

Biol Psychiatry 55:434437 Szewczyk A, Wojtczak L (2002) Mitochondria as a pharmacological target