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22,23 In general, TADs not only facilitate transcription initiation by combining with transcriptional coactivators and transcription machinery elements but also inhibit transcriptional activity by binding to negative regulators

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Oxidative stress responses clarified the functioning of central principal switches like nuclear factor (NF)-B (NFB) or the Kelch-like ECH-associated protein 1 (Keap1)-Nuclear factor erythroid 2-related factor2 (Nrf2)-antioxidant response element (ARE) redox regulator pathway (Sies, 2015

doi: 10.1016/j.mayocp.2021.07.004 24 ChangCJHungLYKogelnikAMKaufmanDAiyarRSChuAMet al