The umbrella term NAFLD includes the pure liver fat accumulation, the so-called hepatic steatosis or non-alcoholic fatty liver, and the progressive form with inflammation, also known as non-alcoholic steatohepatitis, which is related to the increase in oxidative stress and reactive oxygen species, eventually leading to liver fibrosis
Moreover, glucose metabolism is thought to be related to ROS elimination, and a study has shown that glucose deprivation can induce cytotoxicity in MCF-7/ADR human multidrug-resistant breast cancer cells (Gupta et al., 1997
Selenium : A cofactor for glutathione peroxidase, an enzyme that utilizes glutathione to combat oxidative stress
With high energy output from mitochondria comes higher free radical and ROS production and greater susceptibility to oxidative stresswhich is where glutathione comes in again.* The sirtuin SIRT3a longevity-related protein that requires NAD+ for proper functioningis also involved here, helping to maintain hearing during aging by promoting glutathione-mediated antioxidant defense systems