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Gene set enrichment analysis showed upregulation of MYC and p53 targets after 24 hours of oxidative damage, as well as upregulation of pathways related to cell cycle control, DNA repair, and telomere maintenance, and downregulation of glycolysis, T cell receptor complexes, and other metabolic processes

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Dados los diversos roles del GSH en la fisiologa celular, la importancia clnica de la homeostasis alterada del glutatin est incrementando su potencialidad como agente teraputico

HBx differentially regulates LONP1 expression in mitochondrial and cytosolic compartments: it upregulates mitochondrial LONP1 to enhance the UPRmt, while downregulating cytosolic LONP1 to activate the PTEN-induced putative kinase 1 (PINK1)/Parkin signaling axis