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One randomized, double-blind, placebo-controlled trial found no evidence that a daily antioxidant supplement containing 12 mg of -carotene, 500 mg of vitamin C, and 400 mg of vitamin E, when taken for up to 12 months, improved mental performance in elderly people (163)

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Regarding the tolerance dose for CKD patients, a previous dose escalation study has demonstrated that intravenous MSC administration did not cause cell transplantation-related adverse events (AEs) or serious adverse events (SAEs), even when the total dose reached 300 million cells