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Notably, reduced inflammation was accompanied by decreased glomerular hypertrophy, mesangial expansion and type IV collagen deposition

249 , R638R641 (1985)

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Further evaluation for Hirschsprung disease, a spinal cord abnormality, or a metabolic disorder may be warranted in a child with red flags, such as onset before one month of age, delayed passage of meconium after birth, failure to thrive, explosive stools, and severe abdominal distension