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With a 17 mg/mL vial, 5 mg 29 units

[DOI] [PMC free article] [PubMed] [Google Scholar] 101.Shaheen SO, Newson RB, Ring SM, Rose-Zerilli MJ, Holloway JW, et al

Sodium-glucose co-transporters are responsible for 97% of glucose reabsorption6 and their inhibition lowers blood glucose by increasing renal glucose excretion.4 , 5 Using SGLT-2 inhibitors increases the risk of DKA6 , 7 by decreasing daily carbohydrate availability by 20%45%,9 lowering endogenous insulin production and stimulating lipolysis that leads to ketogenesis.6 Patients who also receive insulin may decrease insulin doses in response to lower blood glucose patterns, leading to insulin deficiency

Prices are expected to further decline as KSMs continue to fall in price and competition intensifies For procurement teams and strategy leads, this means a dramatically different cost base and has major implications for development/CMO contracts and price forecasting