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A better understanding of the complex physiology of weight regulation and the role of intestinal hormones in regulating food intake, appetite, and glucose homeostasis led to the discovery of GLP- 1 receptor analogs as safe and effective treatments, initially for T2DM and more recently in higher doses to treat obesity (liraglutide 3 mg and semaglutide 2.4 mg)
Risk factors for greater lean tissue loss likely include advanced age, rapid or large absolute weight loss, low dietary protein intake, sedentary lifestyle, and comorbid conditions such as chronic kidney disease or long-standing diabetes [15]
Furthermore, as a result of their pleiotropic effect on multiple organ systems, these agents are emerging as potential therapy for metabolic dysfunction-associated steatotic liver disease, neurodegenerative conditions, and behavioral health disorders [5, 6]