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However, the physiological half-life of GLP-1 in circulation is very short (less than 2 min), which can be attributed to both rapid proteolytic cleavage of the amide bond of alanine at position 8 (Ala8) in the N-terminus by ubiquitous dipeptidyl peptidase IV (DPP-IV), which results in the removal of the two N-terminal amino acids leading to the formation of a truncated inactive form 10,11 and clearance by the kidney as well

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Disadvantages: In the experiment, the average excretion velocity is usually used instead of the instantaneous excretion velocity, which may introduce some errors

Each ingredient is chosen for its specific role in supporting weight management and overall well-being