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Furthermore, NAD levels in the brain are essential for maintaining central nervous system (CNS) vascular integrity, due to NAD maintaining an energy supply that plays crucial roles in cell survival, such as having a protective factor in cerebral ischemia, since its disorder leads to energy depletion (13, 52)

17 GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE There was little enthusiasm for therapeutic use of GIP in the years after its discovery because GIP infusions had little effect on insulin secretion and appetite regulation in T2D

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