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Your body responds to this energy deficit by increasing the mobilization of fatty acids from adipose tissue

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FABP5 also channels PUFAs into cellular membranes, forming PUFA-containing phospholipids that are intrinsically vulnerable to lipid peroxidation and ferroptosis due to their bis-allylic structure with multiple double bonds [5]

One important feature may be neurogenic claudication which is the onset and worsening of pain, weakness, numbness, tingling, heaviness, or fatigue sensation in the hips, buttocks, and lower limbs that is exacerbated with standing and walking, and improved with sitting or leaning forward on an object such as a shopping cart or walker