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Light microscopic study One lobe of the thyroid gland was fixed in 10% of neutral buffered formalin, dehydrated and embedded in paraffin

Calcium is critical for signal transduction, and it enters mitochondria via osmosis or the action of channels and proteins such as Ca 2+ uniporter complexes transport it [167]

Immunological mechanisms The role of immune system in xenobiotics-induced hepatotoxicity is discussed in previous investigations.55 Immune-mediated reactions are suggested to play a role in antithyroid drug-induced hepatotoxicity.56 Although the mechanism(s) underlying this event is not fully elucidated yet 56, but cytokines are thought to play a role in immunemediated liver injury caused by methimazole.56 Cytokines could play an important role in DILI.57,58 Hence, another possible mechanism(s) for antithyroid drugsinduced hepatotoxicity could be immune system-mediated

Effect of various PDE inhibitors on smooth muscle tone and cyclic nucleotide levels in vitro