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At 0.5, 1, 2, 5, 8, 12, 18, 24, and 36 h, 1 mL aliquots were withdrawn from the receiver compartment for HPLC analysis to quantify the amount of APIs per unit skin area

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For example, a study showed that recombinant GLP-1RA improved endothelial function in patients with type 2 diabetes [5], while another study showed that exenatide increases the plasma concentrations of a number of vasodilators and suppresses the renin-angiotensin system [6]

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