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At least her neurological symptoms are easing and her memory has improved

For renal impairment, although most GLP-1 agents have minimal renal clearance, impaired kidney function increases the risk of adverse events such as dehydration from vomiting or decreased drug clearance in polypharmacy

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Implications for Long-Term Obesity Management This study demonstrates that structured moderate-to-vigorous exercise is the primary driver of improvements in physical fitness during long-term weight maintenance, even when weight loss is supported by GLP-1 RA therapy