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No cases of severe hypoglycemia or diabetic ketoacidosis occurred

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According to Horn and colleagues and Milushewa and colleagues, factors such as initial A1C level, adherence to medication, and other underlying health conditions can influence actual A1C reduction

5.6 Limitations of direct administration and the rationale for delivery systems In moving from laboratory findings to clinical applications, one critical bottleneck is the limited effectiveness of direct administration of therapeutic agents such as probiotics, 6-gingerol, and vitamin D