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et al., Nature Medicine (Vol 30, 2024, pp 20372048)

Traditional weight loss methods generally have a low risk of adverse effects

In one study, more than a quarter of participants in the 12-mg dose group lost 30% or more of their baseline weight, showcasing the drugs potential for dramatic weight reduction

GLP-1 receptor agonists were initially developed to improve glycemic control in type 2 diabetes by enhancing insulin secretion and inhibiting glucagon release, with additional effects on appetite regulation and gastric emptying later recognized as clinically relevant (Chao et al