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a prospective study demonstrated cognitive impairment (overt or subclinical) in 42% of cirrhotics without infection, in 79% with infection and in 90% with sepsis and systemic inflammatory response [30]

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Outcomes vary: Mild cases may improve with treatment Moderate cases may require long-term management Severe cases can become permanent Some patients develop lifelong GI dysfunction after GLP-1 drug use Early diagnosis significantly improves prognosis