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A pilot study on elderly obese diabetic patients also showed that semaglutide effectively reduced body fat while maintaining the percentage of skeletal muscle and the proportion of limb muscle [52]

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TRPV1 is expressed in about 60% of vagal neurons, and TRPA1 in about 25%.[ref] In addition to chemical stimuli, TRP receptors respond to oxidative stress and systemic inflammation.[ref] Repeated activation and hyperexcitability: TRPA1 and TRPV1 receptors are often co-localized on the same cells