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More broadly, there are certain situations in which you should seek prompt medical advice, regardless of whether you are on an investigational medication: Symptoms of a UTI that do not improve within 48 hours contact your GP or use NHS 111 Fever (38C or above), rigors (shivering), or back/flank pain these may indicate a kidney infection (pyelonephritis) and warrant same-day medical assessment

A severe tendon tear, fracture, infection, nerve compression, progressive weakness, unexplained swelling, or rapidly worsening pain needs appropriate evaluation

Alway inform your doctor if you are planning to have a child before getting such treatments

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