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Cash-Pay Positioning: According to Ro's published materials, the platform emphasizes cash-pay access for patients who may not have insurance coverage for weight management medications

Many state Medicaid programs apply BMI thresholds, often a body mass index above 30, sometimes 35 with comorbidities, that exclude patients whose visceral fat and liver fat sit outside those cutoffs

Appetite suppression with retatrutide is typically most effective at higher maintenance doses, so hunger is often more noticeable during the early titration phase

The gastrointestinal system needs time to adapt to delayed gastric emptying