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In detail, erastin inhibits system Xc resulting in cysteine starvation and ferroptotic cell death [20] [21]

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Martinelli D, Diodato D, Ponzi E, Monn M, Boenzi S, Bertini E, Fiermonte G, Dionisi-Vici C (2015) The hyperornithinemia-hyperammonemia-homocitrullinuria syndrome

Mutation of this enzyme leads to fumarate accumulation not only in skin cancer and uterine leiomyomas but also in breast, bladder, and Leydig cell tumors 130