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Abstract GLP-1 receptor agonists (e.g., semaglutide) and dual GLP-1/GIP receptor agonists (e.g., tirzepatide) are effective for reducing body weight and fat mass, though lean soft tissue loss comprised 26%40% of weight loss in recent trials

All treatment decisions are made by a licensed clinician after an in-person evaluation

Many people start with weekly shots, then move to monthly maintenance once levels are stable

Significant legal actions include: The American Psychiatric Association classifies gambling disorder in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5/DSM-5-TR) as the only non-substance addictive disorder, grouped with Substance-Related and Addictive Disorders because it engages the brains reward circuitry in ways comparable to drugs of abuse