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What the conversation covers Unique challenges in type 1 diabetes , why insulin alone has structural limitations The mechanism , how GLP-1 therapies work The evidence in type 1 diabetes , from early studies to ADJUST T1D and tirzepatide Exploration points , what the evidence tends to show on insulin adjustment, monitoring, and nutrition Future directions , triple and quadruple agonists, reimbursement, and paediatric potential Watch or listen Key themes Why insulin alone has structural limitations The episode opens by exploring why insulin alone has structural limitations in type 1 diabetes

They include benefits such as utility assistance and allowances for healthy food purchases

Nevertheless, some drawbacks such as derivatization, cumbersome laboratory procedures, time consumption and applicable feasibility in vivo were not conducive to the development of a practical method

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