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Furthermore, fibrosis severity correlated with smoking index and coexistent diabetes, reinforcing a dose-dependent effect

It has become a valuable tool in various stages of drug development, including first-in-human dose calculation, predicting DDI potential, and assessing pharmacokinetic profiles in special populations such as pediatrics and patients with renal or hepatic impairment.222,223 In particular, it is widely used to predict potential pharmacokinetic DDIs of small molecules.224 Physiological properties of the body, including organ mass and volume, blood flow rate, plasma protein levels, and the abundance of enzyme and transporter expression, are mathematically described within the model.225,226 Therefore, the mechanism of action of GLP-1 RAs and a dual GLP-1/GIP RA can be characterized by modulating physiological properties within the model, enabling the prediction of altered pharmacokinetics for the affected drug

CrossRef Non-Hispanic Black Persons With HIV Have a Lower Risk of Metabolic DysfunctionAssociated Steatotic Liver Disease and Clinically Significant Fibrosis Compared to Non-Hispanic White and Hispanic Individuals Tinsay A Woreta, Samer Gawrieh, Laura A Wilson, Yuchen Xin, Eduardo Vilar-Gomez, Kathleen E Corey, Richard K Sterling, Jordan E Lake, Susanna Naggie, Sonya Heath, Holly Crandall, Jennifer C Price, Rohit Loomba, Naga Chalasani, Mark S Sulkowski Open Forum Infectious Diseases .2026;[Epub] CrossRef Nuclear translocation of GPS2 promotes activation of hepatic stellate cells by fatty acid oxidation pathway Haiqin Hong, Li Wang, Muran Lu, Ziyi An, Yanxia Shi, Qi Deng, Jingjing Wu, Benwei Wang, Jialu Lu, Mengjun Li, Yan Huang, Weili Lu, Fanrong Wu Life Sciences .2026

The development of 3D organoid models, CRISPR-based functional screens, and AI-driven multiomics analysis is paving the way for precision-targeted CSC therapies