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However, progression to fibrosis also occurs in patients with steatosis alone [7], although rates of progression and overall mortality rates are increased in NASH [1, 8]

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In a Phase 2 trial published in 2023, adults with obesity who received retatrutide weekly for 48 weeks lost up to 24.2% of their body weight on the highest dose nearly a quarter of their weight on average

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A relative and an absolute increase in the number of monocytes has also been reported (380)

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