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For instance, studies have highlighted the association between increased abundance of particular bacterial species, notably Akkermansia muciniphila, and enhanced metabolic health outcomes

Such a direct GLP-1 mechanism is supported by studies using native GLP-1 and exenatide in healthy people and patients with T2DM showing that the acute increase of HR was not preceded by a decrease in blood pressure, was not associated with changes in plasma levels of adrenaline or noradrenaline, and was independent of GLP-1 glucoregulatory effects [11, 34, 35]

Proc Natl Acad Sci USA 92: 39483952

In fact, the in vivo studies suggest that an active crosstalk between IGF1 and estrogen is indeed a precondition for cortical bone mechanical strain response (288)