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Antioxidant defense via Nrf2 pathway activation Oxidative stress, the accumulation of reactive oxygen species that damage cells, mitochondria, and DNA, is a foundational driver of accelerated aging

doi: 10.1128/MCB.01145-09

However, results vary significantly between individuals

acts on reward circuitry Setmelanotide (Imcivree): MC4R agonist for genetic obesity (LEPR, POMC deficiencies) SGLT2 inhibitors (empagliflozin, dapagliflozin): Not FDA-approved for obesity alone but cause weight loss