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Atractylenolide I can enhance Lactobacillus and Bacteroides , reduces the levels of Escherichia and Candidatus , and by suppressing the TLR4/MyD88/NF-B pathway to reduce IL-1 and LPS levels ( Actinobacteria growth, elevates Bacteroidetes levels (Ren et al., 2021)

Stphanie Decollogne for critical reading of the manuscript and Prof

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Emerging animal studies also point to possible joint and cartilage benefits, particularly when paired with hyaluronic acid therapy