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Sendamangalam V

In mice subjected to social defeat stress, brain lactate levels and lactylation correlate positively with neuronal activity, suggesting that lactylation contributes to neural regulation in depression and anxiety (Hagihara et al., 2021)

The problem: very short half-life (~50 minutes) and 3 daily injections at meals , an extremely impractical regimen

Blinding was not performed during animal experiments and data collection, but outcome assessments (e.g., IHC scoring) were conducted by blinded investigators