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This is why conservative starting doses of 0.5 to 2 mg are recommended, compared to the relatively higher starting point of 2.5 mg for tirzepatide

Diarrhoea was reported in approximately 2030% of participants at higher doses in the phase 2 trial

See, e.g., FDA warning letter to Eurosirel S.P.A

Teva Pharmaceuticals Press Release on Generic Saxenda Approval Saxenda review FDA APPROVES WEGOVY (SEMAGLUTIDE) FOR MASH (FATTY LIVER DISEASE) August 2025 Metabolic dysfunctionassociated steatohepatitis (MASH), also known as fatty liver disease, is a condition strongly associated with obesity that causes chronic liver inflammation and scarring