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Despite the relatively recent development of GLP-1RAs, international diabetes guidelines recognize the benefits of this class of drugs and recommend them as a treatment option for patients with type 2 diabetes

It can induce cell migration, MMP activation, and collagen remodeling through the APPL1-AMPK molecular axis [175], while in other settings adiponectin inhibits fibrosis via the AdipoR1-AMPK-iNOS pathway [176]

This method is commonly used for vaccines, antibiotics, hormone therapies, and other medications that require rapid or sustained absorption and are not suitable for oral delivery

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