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The effect was nominally significant for the GIPR/GLP-1R agonist (Beta: 0.35, 95%CI: 0.010.69, P = 0.046), while the associations for the GCGR/GLP-1R agonist (Beta: 0.28, 95%CI: 0.070.49, P = 7.97 10 3 ) and the GCGR/GIPR/GLP-1R agonist (Beta: 0.39, 95%CI: 0.110.66, P = 5.67 10 3 ) remained significant after multiple testing (Fig

Resmetirom received FDA approval for the fibrotic stage, but the steatosis stage, where the vast majority of patients sit, has no approved pharmacological intervention

People on the maximum dose lost an average of 85 lb after 104 weeks, or slightly more than 30 percent of their starting body weight

When considering any medication, its crucial to weigh the risk-benefit ratio