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Excess FFA (NEFA) also participate in the relocation of several protein kinase C (PKC) isoforms from the cytosol to the membrane compartment

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In a clinical trial using silymarin in alcoholic patients with confirmed liver cirrhosis, silymarin (150 mg/three times per day) administered for two years and no influence of silymarin was seen in case of survival and clinical course of the disease in comparison to the sham group (6)