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Best Pract Res Clin Obstet Gynaecol

1995;10(Suppl 2):2S3-2S7

Studies on individuals undergoing rapid weight loss show that those performing resistance exercise 34 times weekly retain 7080% more lean mass compared to those relying on diet alone

The underlying mechanisms have not been fully delineated but are likely to involve modulation of the brain dopamine reward system via GLP-1 receptors, which are present both in the ventral tegmental areas (VTA), where dopamine neurons are located, and in the nucleus accumbens (NAc), which is the main projection of VTA dopamine neurons 14