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Principles of infectious diseases: transmission, diagnosis, prevention, and control

Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions

Given that the degradation of KEAP1 encompasses two distinct pathways, namely autophagy 29 and proteasomal degradation 30 , we employed the protein synthesis inhibitor cycloheximide (CHX), the proteasome inhibitor MG132, and the autophagy inhibitor chloroquine (Chlq) to further explore the underlying mechanism in macrophages (Fig

The sulphur atom on cysteine carries a hydrogen, forming the thiol group (-SH) that gives glutathione its working surface