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As for mortality, both SGLT-2 inhibitors and GLP-1RA are similar in reducing both total and CV deaths, but SGLT-2 inhibitors only are superior to DPP-4 inhibitors for both deaths, whereas GLP-1RA are superior to DPP-4 inhibitors for total death, but equal for CV death

They should also be able to quickly and clearly articulate their quality control systems and procedures including the name of the third-party testing lab they utilize. If the pharmacy itself is preparing the compounded drug, ask where they source the active ingredient they use, says Brunner

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The questions that Phase 3 will need to answer and that regulators will scrutinize closely include cardiovascular outcomes over extended periods, liver function changes beyond the 48-week window, potential interactions with other metabolic agents, and safety in populations not well-represented in Phase 2