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demonstrated that erythrocytes possess Fas, FasL, FADD, showing that erythrocytes could form the DISC downstream of which caspase-8 and caspase-3 were activated [136]

Later, following the discovery of other isozymes with broader substrate specificity and tissue-specific localization, the cytosolic GPx from erythrocytes utilizing hydroperoxide (inorganic/organic) and GSH as the substrates was termed GPx1

One area of growing interest is the impact of NSAIDs on glutathione, a crucial antioxidant that plays a role in protecting the body from oxidative stress and supporting overall wellness

Several developments could significantly advance understanding of this compound in the coming years