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ABSTRACT Glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter 2 inhibitors (SGLT-2is) have been shown to provide extra-glycemic advantages, such as cardiovascular and renal protection, in the treatment of type 2 diabetic mellitus (T2DM)

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Third, the low event rate, 17 cases in the tirzepatide group and 33 in the control group, limits statistical power and magnifies the impact of potential misclassification