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The selectivity of DPP4 inhibitors and the importance of DPP4 for enzymatic inactivation of key substrates is of great interest because DPP7, DPP8, DPP9, and FAP also display DPP4-like activity (DPP4L1 and DPP4L2 do not because they have a mutation at the active site serine) (152, 153)