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The liver continues to produce bile, even without the gallbladder, and the primary mechanisms of GLP-1s (insulin regulation, gastric emptying, appetite suppression) operate independently of gallbladder function

Animal experiments All in vivo procedures were conducted according to the guidelines from the regional Ethics Committee for Animal Research, Skane, Sweden (permit nos

A natural small molecule aspidosperma-type alkaloid, hecubine, as a new TREM2 activator for alleviating lipopolysaccharide-induced neuroinflammation in vitro and in vivo

Compounds that affect gastric motility or bile production require more consideration, as they may amplify or reduce GI effects