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Some researchers hypothesize that anti-inflammatory effects might also benefit neurodegenerative conditions, though this remains highly investigational

Patients with type 2 diabetes and elevated inflammatory markers, particularly those with established cardiovascular disease or high cardiovascular risk, represent a group where GLP-1 receptor agonists are already recommended by the ADA and American College of Physicians (ACP)

26 The two versions of GLP-1 are ~50% homologous with glucagon, 189 and they both have similar affinity for the GLP-1R and also exhibit similar potency

[15] [16] There is currently no licensed pharmacological treatment for MASLD in the UK, making retatrutide a potentially important therapeutic candidate, though this remains to be confirmed in Phase 3 trials