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articles Retatrutide TRIUMPH-2/3: 22.6% Loss in Diabetes & CVD Lilly's retatrutide met endpoints in two new Phase 3 trials up to 22.6% weight loss in obesity with diabetes and heart disease

They work best when part of a structured program that includes dietary guidance, regular physical activity, and medical supervision

Combining it with a GLP-1 agonist is showing promising results

For example, in a 2021 study, as little as 100mg of dihydroberberine increased berberine blood levels better than 500mg of HCl, and another 2021 study (by Indena, the company that makes Berbevis) found that a phytosomal preparation resulted in a tenfold improvement in bioavailability compared with HCl.48 51 Based on these studies, you might conclude that the two bioenhanced forms are superior to berberine HCl