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A dysfunctional OCTN2 transporter reduces this gradient because of a compromised myocardial carnitine transport as well as a result of low plasma carnitine concentration subsequent to excessive renal loss of carnitine

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Further, NOS activity and cytosolic protein content was evaluated in Sprague-Dawley rats at 0300, 0900, 1500, and 2100 h in various regions of the brain including cerebellum, brainstem, hypothalamus, and hippocampus and reported that a significant upregulation during the dark (active) period (Denniff et al., 2014)