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Aberrant cytoplasmic and nuclear accumulation of -catenin often reflects underlying CTNNB1 mutations, commonly observed in endometrioid neoplasms

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Some studies cited in a 2025 review noted that while proline can protect cells at low levels, when metabolized by the enzyme proline oxidase it produces reactive oxygen species (ROS)

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Gastroenterology 113 , 11801187 (1997)

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