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In using ivermectin MDA in areas where multiple endoparasites and ectoparasites exist, the dosage and regimen that is chosen (likely the discriminating dose of the priority organism) will likely be used at the expense of other organisms and may result in a shorter time-to-emergence of resistance in the latter

doi: 10.1002/hsr2.291 39 ChenPWangDXiuMChenDLackeyBWuHEet al

153,154 It hosts numerous phosphorylation sites across its N-terminal region, C-terminal region, and repeat region, which are regulated by a balance of various kinases and phosphatases to maintain normal neuronal physiological functions

Combination approach needed